Involvement of vascular endothelial growth factor receptor-1 in rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Serum vascular endothelial growth factor in late rheumatoid arthritis.
OBJECTIVES To investigate the serum levels of VEGF in patients with rheumatoid arthritis of long duration. METHODS Serum VEGF levels were measured in 118 patients with long-standing rheumatoid arthritis according to the ACR criteria (mean duration 12 years). The disease activity score was evaluated by the method of van der Heijde et al. RESULTS Serum levels of VEGF in patients with RA were ...
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Vascular endothelial growth factor (VEGF) and VEGF receptor-1 (VEGFR-1/Flt-1) were shown to be involved in pathological angiogenesis, particularly rheumatoid arthritis (RA). However, the molecular basis of their actions is not fully understood. Here we report that in a murine model of RA, deletion of the tyrosine kinase (TK) domain of VEGFR-1 decreased the incidence and clinical symptoms of RA....
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ژورنال
عنوان ژورنال: Inflammation and Regeneration
سال: 2008
ISSN: 1880-9693,1880-8190
DOI: 10.2492/inflammregen.28.78